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MOTS-c Injectable in its pharmacy container
Pharmacy Peptides · InjectableNew

MOTS-c Injectable, 40 mg

A licensed provider approves before anything ships.

Made by a 503A facility for your prescription. Compounded drugs are not FDA-approved and are not the same as brand-name medications.

$239.99/mo

Plus a 3% service fee and any state tax at checkout.

3-month minimum: cancel before month 3 and it's $35 for each month left. No fee after that.

Strength

Your provider confirms the strength that fits.

How to buy

LegitScript certifiedUS-licensed providers503A facility

$247.19 a month with the 3% service fee and free shipping. Plus any state tax.

Quick facts

Form
Injectable vial
Size
40 mg
How you get it
A prescription by a licensed provider
Made by
Made by a 503A facility for your prescription.
Ingredients
One ingredient per product. Never blended.

How this works

  • Prescribed for youA US-licensed provider reviews your history before anything is filled, and decides whether it's right for you.
  • Filled for your prescriptionMade by a 503A facility for your prescription. Shipped to you. Syringes and alcohol prep pads included.
  • LegitScript certifiedIndependently checked for safe, legal telehealth practice. See our certification
  • Not approved? You pay nothingIf the provider doesn't approve it, it's refunded in full automatically.

What “not FDA-approved” means: compounded medicines are made by a licensed pharmacy and filled for an individual prescription. The FDA doesn't review compounded medicines for safety, effectiveness or quality before they're dispensed, the way it reviews approved drugs. Your provider decides whether one is right for you.

  • 503A facility
  • Single ingredient
  • Prescription required
HHS policy on hhs.gov
Is this right for you?

It may fit if:

  • You want a licensed provider to review your history before anything is prescribed
  • You want one ingredient, made for your prescription. Made by a 503A facility for your prescription.
  • You want to know who made it and how to report a problem
  • You'd rather not buy something labeled “not for human use”
  • You're comfortable with an injection, with directions from your provider

A licensed provider decides whether it's right for you, after reviewing your intake.

Research

What the research says (and doesn't)

What researchers have studied, and what they have not shown. None of this is a claim about what this peptide does for you; your provider talks with you about what is and isn't known.

Studied

  1. Animal study

    In 2015, researchers reported a 16-amino-acid peptide encoded in the mitochondrial 12S rRNA gene and named it MOTS-c. The work was in cells and mice, including age-related and diet-induced models of insulin resistance.

    “Here we report a sORF within the mitochondrial 12S rRNA encoding a 16-amino-acid peptide named MOTS-c.”

  2. Animal study

    A 2021 study measured physical performance in young, middle-aged and old mice given MOTS-c.

    “MOTS-c can significantly enhance physical performance in young (2 mo.), middle-age (12 mo.), and old (22 mo.) mice.”

  3. Small human study

    The same 2021 study measured the body's own MOTS-c in 10 healthy young men at rest and following exercise. No MOTS-c was given to these men.

    “In humans, exercise induces endogenous MOTS-c expression in skeletal muscle and in circulation.”

  4. Registered trial, no results

    A randomized, double-blind, placebo-controlled Phase 1a/1b trial of CB4211, a MOTS-c analogue (not MOTS-c itself), enrolled 88 people and finished in April 2021. It has posted no results.

    “This is a 3 part, randomized, double blind, placebo controlled study evaluating the safety, tolerability,”

  5. FDA review

    FDA found that MOTS-c research was limited to cell and rodent studies, with molecular targets unknown and no dose-response assessment, and found no human data on MOTS-c drug products.

    “FDA is particularly concerned about the lack of human data on drug products containing this substance”

Not shown

  • No published human trial of MOTS-c itself was found. The only completed controlled human exposure is to an analogue, and its results have not been posted or published.
  • The metabolic and exercise findings come from mice. The human data measure the body's own MOTS-c; none was dosed.
  • FDA: molecular targets unknown, potential safety risks in humans unknown, and immunogenicity and impurity concerns.
  • A randomized Phase 2 trial of subcutaneous MOTS-c in adults with prediabetes is registered in China and has no results yet.

MOTS-c is not FDA-approved. In briefing documents for its July 23–24, 2026 Pharmacy Compounding Advisory Committee meeting, FDA proposed not adding MOTS-c to the 503A bulks list; the committee's votes and any final FDA decision were not found. HHS's interim policy describes the conditions under which HHS does not intend to act against a 503A pharmacy that compounds it for a patient's own prescription.

FDA PCAC briefing document, MOTS-c (July 2026) HHS interim peptide policy (Appendix B)

If you compete in tested sport: FDA's briefing notes that MOTS-c appears as a prohibited substance in Global DRO, which draws on the WADA Prohibited List. Source

Sources: FDA, NIH/PubMed, ClinicalTrials.gov, USADA, HHS

What you should know

What it is

MOTS-c is a 16-amino-acid peptide. It is one of the six peptides in an interim HHS policy for compounding pharmacies. Compounded drugs are not FDA-approved and are not the same as brand-name medications. Nothing is made or shipped until a licensed provider approves it for you. If a provider says it's not right for you, you pay nothing.

Who it's for

You want a peptide prescribed by a licensed provider, not a research-use vial. You want one ingredient, made for your prescription. You want a person to ask between visits.

What comes in the box

Your MOTS-c Injectable, 40 mg, the syringes and alcohol prep pads you need for each injection, and the pharmacy insert, shipped cold-packed.

Can I get MOTS-c with a prescription?

Yes, by prescription. MOTS-c is one of the six peptides in HHS's interim policy (October 2026). A licensed provider decides whether it's right for you; if it is, it's made for your prescription by a 503A facility and shipped to you. Compounded drugs are not FDA-approved and are not the same as brand-name medications.

Do I need a membership for MOTS-c?

No. You can order MOTS-c on its own: a short intake, a licensed provider's approval, and your prescription made and shipped. A membership adds four lab panels and four provider visits a year and a wellness consultant between visits.

How it's made

Made by a 503A facility for your prescription. One ingredient per product. Never blended. It is labeled with your name and your prescription.

Who sets the dose?

Your provider sets the dose.

Is it FDA-approved?

No. Compounded drugs are not FDA-approved and are not the same as brand-name medications. The HHS policy that covers it is not FDA approval, and HHS can revisit it.

Side effects and reporting

Tell your care team about anything you notice. Anyone can also report a side effect to the FDA through MedWatch.

Build your plan

Often paired with MOTS-c Injectable, 40 mg.

Labs + Provider + Person = Your plan

Membership from $89.92/mo

4 Labcorp lab panels, 4 provider visits and a wellness consultant every year, on the annual plan. $149.99 month to month.

Start membership